Functional dissection of complex trait variants at single-nucleotide resolution

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homebrew-core has one Ruby file per package formula, and every brew update used to clone or fetch the whole repository until it got large enough that GitHub explicitly asked them to stop. Homebrew 4.0 switched to downloading a JSON file over HTTP, because users wanted the current state of a package rather than its commit history. But updating a formula still means opening a pull request against homebrew-core, because git is where the collaboration tooling lives. Instead of using git as a database, what if you used a database as a git?

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I thought it was time to try a similar experiment myself, one that would take one or two hours at max, and that was compatible with my Claude Code Max plan: I decided to write a Z80 emulator, and then a ZX Spectrum emulator (and even more, a CP/M emulator, see later) in a condition that I believe makes a more sense as “clean room” setup. The result can be found here: https://github.com/antirez/ZOT.

The Eufy O

«Роберт Де Ниро — еще один больной и дементный человек, думаю, что с чрезвычайно низким IQ. Он абсолютно не понимает, что делает или говорит, что его заявления являются серьезными преступлениями», — сказал глава Белого дома.